High-frequency ultrasound in orthotopic pancreatic cancer models

High-frequency ultrasound in Power Doppler Mode (Vevo 2100 imaging system, FujiFilm VisualSonics, thanks to the help of Dr. Dieter Fuchs) was carried out to evaluate tumor vascularization.
This high-resolution ultrasound instrument provided a non-invasive anatomical image of tumors or normal abdominal organs with an axial resolution of 40 μm, allowing multiple focal depths and improved feature detection. In particular, we observed hypovascular pancreatic tumors below 900 μm in diameter.

This video has been published as Supplemental file to the article:

Avan A, Caretti V, Funel N, Galvani E, Maftouh M, Honeywell RJ, Lagerweij T, Van Tellingen O, Campani D, Fuchs D, Verheul HM, Schuurhuis GJ, Boggi U, Peters GJ, Würdinger T, Giovannetti E.
Crizotinib inhibits metabolic inactivation of gemcitabine in c-Met-driven pancreatic carcinoma
Cancer Res. 2013 Nov 15;73(22):6745-56
Link: www.ncbi.nlm.nih.gov/pubmed/24085787