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Video ecografia sui modelli marini
published novembre 15, 2013
posted in Our videos
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High-frequency ultrasound in orthotopic pancreatic cancer models

High-frequency ultrasound in Power Doppler Mode (Vevo 2100 imaging system, FujiFilm VisualSonics, thanks to the help of Dr. Dieter Fuchs) was carried out to evaluate tumor vascularization.
This high-resolution ultrasound instrument provided a non-invasive anatomical image of tumors or normal abdominal organs with an axial resolution of 40 μm, allowing multiple focal depths and improved feature detection. In particular, we observed hypovascular pancreatic tumors below 900 μm in diameter.

This video has been published as Supplemental file to the article:

Avan A, Caretti V, Funel N, Galvani E, Maftouh M, Honeywell RJ, Lagerweij T, Van Tellingen O, Campani D, Fuchs D, Verheul HM, Schuurhuis GJ, Boggi U, Peters GJ, Würdinger T, Giovannetti E.
Crizotinib inhibits metabolic inactivation of gemcitabine in c-Met-driven pancreatic carcinoma
Cancer Res. 2013 Nov 15;73(22):6745-56
Link: www.ncbi.nlm.nih.gov/pubmed/24085787

Comprehensive arrays identify key microRNAs to distinguish short and long survivors among resected pancreatic cencer patients
published ottobre 1, 2013
posted in Presentations
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Comprehensive arrays identify key microRNAs to distinguish short and long survivors among resected pancreatic cencer patients

Elisa Giovannetti

Presentation on “miRNA arrays” at European Society of Medical Oncology meeting (ESMO-ECCO) 2012

VU University Medical Center
Amsterdam, The Netherlands

European Cancer Congress 2013
Amsterdam, 27 Sept / 1 Oct 2013

Pdf: ESMO-ECCO2013

Farmacogenomica nelle neoplasie polmonari
published settembre 20, 2013
posted in Presentations
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Farmacogenomica nelle neoplasie polmonari

Elisa Giovannetti

Invited seminar on “Pharmacogenetics of Thoracic Cancers”, Parma 2013

Department Medical Oncology, VU University Medical Center,
Amsterdam, The Netherlands

Thoracic Oncology: Where are we going?
Parma, 20 September 2013

Pdf: Seminar-Parma2013

Press release of our International Journal of Cancer paper for AIRC
published luglio 7, 2013
posted in News
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Press release of our International Journal of Cancer paper for AIRC

Determinanti farmacogenetici per guidare la chemioterapia dei tumori pancreatici

Grazie al finanziamento AIRC, ricercatori italiani e olandesi hanno valutato determinanti farmacogenetici correlati con la prognosi di pazienti affetti da tumori pancreatici trattati con nuovi schemi polichemioterapici.

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CCA Foundation grant and the Amsterdam Marathon
published ottobre 18, 2012
posted in News
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CCA Foundation grant and the Amsterdam Marathon

Dr. Giovannetti (in collaboration with Dr. Schuurhuis and Dr. Wurdinger) won a CCA Foundation grant, and the picture of all the winners was used in the advertisement of this Foundation during the Amsterdam Marathon 2012.

See: CCA leaflet

Pharmacogenetics to improve new therapeutic approaches in pancreatic cancer
published giugno 25, 2011
posted in Presentations
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Pharmacogenetics to improve new therapeutic approaches in pancreatic cancer

Elisa Giovannetti, MD, PhD

Invited Youppie Lecture at the European Pancreatic Club (EPC) Meeting 2011

VU University Medical Center, Amsterdam, The Netherlands
University of Pisa, Pisa, Italy

43st Meeting of the European Pancreatic Club (EPC) 2011
Magdeburg, 21-25 June 2011

Pdf: EPC2011-YouppieLecture

published giugno 1, 2010
posted in Our previous 5 most representative/cited articles, Publications
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MicroRNA-21 in pancreatic cancer: correlation with clinical outcome and pharmacologic aspects underlying its role in the modulation of gemcitabine activity

Giovannetti E, Funel N, Peters GJ, Del Chiaro M, Erozenci LA, Vasile E, Leon LG, Pollina LE, Groen A, Falcone A, Danesi R, Campani D, Verheul HM, Boggi U
Cancer Res. 2010 Jun 1;70(11):4528-38

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published giugno 1, 2010
posted in Our videos
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Laser-microdissection of pancreatic ductal adenocarcinoma tissues

Example of Laser-microdissection of pancreatic ductal adenocarcinoma tissues using the LMD7000 instrument (Leica Microsystems, Wetzlar, Germany, thanks to the help of Dr. Mauro Baron). The precision of the narrow focus of the laser beam allowed to pickup specimens with high degree of accuracy and extremely low risk of contamination.

This video has been published as supplemental file to the article:

Giovannetti E, Funel N, Peters GJ, Del Chiaro M, Erozenci LA, Vasile E, Leon LG, Pollina LE, Groen A, Falcone A, Danesi R, Campani D, Verheul HM, Boggi U.
MicroRNA-21 in pancreatic cancer: correlation with clinical outcome and pharmacologic aspects underlying its role in the modulation of gemcitabine activity
Cancer Res. 2010;70:4528-38
Link: www.ncbi.nlm.nih.gov/pubmed/20460539

MicroRNA-21 (miR-21) in pancreatic adenocarcinoma: correlation with clinical outcome and pharmacological aspects underlying its role in the modulation of gemcitabine activity
published aprile 21, 2010
posted in Presentations
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MicroRNA-21 (miR-21) in pancreatic adenocarcinoma: correlation with clinical outcome and pharmacological aspects underlying its role in the modulation of gemcitabine activity

Elisa Giovannetti, Niccola Funel, Ayse Erozenci, Marco Del Chiaro, Leticia G. Leon, Enrico Vasile, Luca E. Pollina, Annemieke Groen, Alfredo Falcone, Daniela Campani, Ugo Boggi, Henk M. Verheul, Romano Danesi, Godefridus J. Peters

Presentation on “miR21 in PDAC” at American Association for Cancer Research (AACR) Meeting 2010

VU University Medical Center, Amsterdam, The Netherlands
University of Pisa, Pisa, Italy

AACR 10st Annual Meeting
Washington, 17-21 April 2010

Pdf: AACR2010

Polymorphisms in AKT1 and EGFR as possible new biomarkers of clinical outcome and toxicity in non-small-cell lung cancer patients treated with gefitinib
published ottobre 16, 2009
posted in Presentations
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Polymorphisms in AKT1 and EGFR as possible new biomarkers of clinical outcome and toxicity in non-small-cell lung cancer patients treated with gefitinib

Giovannetti E, Zucali PA, Tibaldi C, Leon GL, Cortesi F, D’Incecco A, Falcone A, Santoro A, Smit EF, Burgers S, Danesi R, Giaccone G, Peters GJ

Presentation on “SNPs in Akt” at EORTC-NCI-ASCO (ENASCO) 2009

EORTC-NCI-ASCO Meeting
Brussels, 16th October 2009

Pdf: ENASCO2009

published luglio 20, 2008
posted in Our videos
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Primary pancreatic cancer cell cultures

These cells and the methodology used for their isolation have been described in the article:

Funel N, Giovannetti E, Del Chiaro M, Mey V, Pollina LE, Nannizzi S, Boggi U, Ricciardi S, Del Tacca M, Bevilacqua G, Mosca F, Danesi R, Campani D.
Laser microdissection and primary cell cultures improve pharmacogenetic analysis in pancreatic adenocarcinoma
Lab Invest. 2008 Jul;88(7):773-84.
Link: www.ncbi.nlm.nih.gov/pubmed/18490900

published marzo 15, 2008
posted in Our previous 5 most representative/cited articles, Publications
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Correlation of CDA, ERCC1, and XPD polymorphisms with response and survival in gemcitabine/cisplatin-treated advanced non-small cell lung cancer patients

Tibaldi C, Giovannetti E, Vasile E, Mey V, Laan AC, Nannizzi S, Di Marsico R, Antonuzzo A, Orlandini C, Ricciardi S, Del Tacca M, Peters GJ, Falcone A, Danesi R
Clin Cancer Res. 2008 Mar 15;14(6):1797-803

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Determinants of erlotinib and pemetrexed synergism in non-small cell lung cancer (NSCLC) cell lines
published marzo 10, 2007
posted in Presentations
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Determinants of erlotinib and pemetrexed synergism in non-small cell lung cancer (NSCLC) cell lines

Giovannetti E, Smid K, Tekle C, Mey V, Rodriguez JA, Nannizzi S, Del Tacca M, Danesi R, Giaccone G, Peters GJ

Presentation on “erlotinib-pemetrexed synergisms” at the Targeted Anticancer Agents (TAT) Meeting 2007

VUMC, Amsterdam, The Netherlands
University of Pisa, Italy

International Symposium on Targeted Anticancer Therapies (TAT 2007)
Amsterdam, 7/10 March 2007

Pdf: TAT2007

published aprile 1, 2006
posted in Our previous 5 most representative/cited articles, Publications
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Transcription analysis of human equilibrative nucleoside transporter-1 predicts survival in pancreas cancer patients treated with gemcitabine

Giovannetti E, Del Tacca M, Mey V, Funel N, Nannizzi S, Ricci S, Orlandini C, Boggi U, Campani D, Del Chiaro M, Iannopollo M, Bevilacqua G, Mosca F, Danesi R
Cancer Res. 2006 Apr 1;66(7):3928-35

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published luglio 30, 2005
posted in Our previous 5 most representative/cited articles, Publications
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Cellular and pharmacogenetics foundation of synergistic interaction of pemetrexed and gemcitabine in human non–small-cell lung cancer cells

Giovannetti E, Mey V, Nannizzi S, Pasqualetti G, Marini L, Del Tacca M, Danesi R
 Mol Pharmacol. 2005 Jul;68(1):110-8

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Farmacogenetica di gemcitabina e pemetrexed nei tumori pancreatici
published giugno 2, 2005
posted in Presentations
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Farmacogenetica di gemcitabina e pemetrexed nei tumori pancreatici

Giovannetti E, Mey V, Danesi R, Funel N, Nannizzi S, Boggi U, Campani D, Pasqualetti G, Orlandini C, Iannopollo M, Del Chiaro M, Ricci S, Bevilacqua G, Mosca F, Del Tacca M

Presentation on “Farmacogenetica di gemcitabina e pemetrexed” at Societa’ Italiana di farmacologia (SIF) 2005

Divisione di Farmacologia e Chemioterapia, Divisione di Chirurgia, Divisione di Anatomia Patologica, Divisione di Oncologia, Dipartimento di Oncologia, dei Trapianti e delle Nuove Tecnologie in Medicina, Università di Pisa

XXXII Congresso Nazionale della Società Italiana di Farmacologia
Napoli, 2 Giugno 2005

Pdf: SIF2005

Determinants of Gemcitabine-Pemetrexed Synergism in Pancreatic Cancer Cell Lines
published aprile 26, 2004
posted in Presentations
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Determinants of Gemcitabine-Pemetrexed Synergism in Pancreatic Cancer Cell Lines

E. Giovannetti, V. Mey, R. Danesi, I. Mosca, M. Del Tacca

Presentation on “Gemcitabine-pemetrexed synergism” at the International Pancreas Cancer Symposium 2004

Division of Pharmacology and Chemotherapy, Department of Oncology, Transplants and Advanced Technologies in Medicine, University of Pisa, Italy

Pancreas Cancer 2004 International Symposium
Tirrenia, Pisa, 24-26 April 2004

Pdf: PancreasCancer2004